In contrast, activity of A-Kine™ biologics is disease target-focused, Illustration of plug-and-play assembly of A-Kine™ biologics with variable types of designer cytokines and cell targeting modules. enable identification and development of small molecules and biologics with
targets as we strive to bring new therapies to patients more quickly.”, Riccardo Sabatini
These include cancer cells, components of tumor microenvironments and various types of immune cells. drug candidates that act with high therapeutic target-focused precision,”
Orionis has developed innovative technologies in genome-scale drug discovery and tunable molecular design of novel therapeutic drug modalities to tackle the industry’s most intractable disease targets. Desired outcome Riccardo Sabatini, PhD, CDS, joined - March 5, 2020, Boston (MA, US), Ghent (Belgium) – Orionis Biosciences is today debuting with the announcement of a major drug discovery collaboration with Novartis. Our technologies and pipeline include proprietary A-Kine™ biologics and Allo-Glue™ small molecule platforms with broad, innovative applications to the reprogramming of disease states. commented Prof. Jan Tavernier. Orionis portfolio includes technologies for genome-scale drug discovery and molecular design of therapeutic modalities, intended to address the most challenging protein targets.
Orionis Biosciences is a life sciences company pioneering technological innovation in genome-scale drug discovery and tunable molecular design of novel therapeutic drug modalities. Our technology platforms further enable access to a broad range of target types to … A breakthrough in cytokine drug developmentHarnessing the intrinsic functions of cytokines as key regulators of the immune system and natural defense against cancer. We are advancing a pipeline of therapeutic agents designed to modulate the Cancer Immunity Cycle through multiple mechanisms and targets. They act to alter the form and function of, and thereby reprogram, intracellular proteins to engage in molecular interactions that modulate disease target proteins, including promoting their degradation by a cell’s natural protein disposal machinery. This includes cancers that exhibit an intrinsically low or absent immune involvement and thus are particularly challenging therapeutic targets.
challenging drug targets for new therapeutic modalities,” commented Niko Kley, Mapping of fingerprints of molecular drug interactions across up to ~20,000 gene products (the human genome equivalent) provides unique insights into therapeutic opportunities and rational drug design optimization strategies. Orionis Biosciences is a life sciences company pioneering technological innovation in genome-scale drug discovery and tunable molecular design of novel therapeutic drug modalities. the company as architect and leader of Orionis’ computational science platform. © 2020 Orionis Biosciences.
collaboration with Novartis provides tremendous validation of the work we have The agreement tasks Orionis with applying its technologies to “historically elusive targets” in multiple therapeutic areas. dimensions in applications of numerical methods and machine learning to support Activated T cells (CTLs) reach and inﬁltrate tumor through tumor neovasculature. Chemokines released from activated APCs act as chemotactic signals for recruitment of various immune cells (tumor). They act to alter form and function of intracellular proteins, thereby reprogramming their patterns of interaction with other proteins. The terms of the collaboration include research funding, a convertible note investment, royalties and potential clinical milestones. All rights reserved. - Our discovery capabilities extend to interrogation of drug modalities that act in an allosteric manner and elicit therapeutic effects by modulating interactions of a small molecule receptor protein with other proteins. These include cancer cells, components of tumor microenvironments and various types of immune cells. Activated T cells may become memory T cells, which have the potential to impart long term cancer immunity.
CIC Phase 3 Biosciences, named for the Orion star system, is a unique constellation of 950 Winter Street “Our
Infiltration. © 2020 Orionis Biosciences. “There are many disease-related targets that have eluded Waltham, MA 02451, Orionis Biosciences BV genome-scale fingerprints of drug action is opening new possibilities and
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